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KMID : 1146920190490040427
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Journal of Pharmaceutical Investigation
2019 Volume.49 No. 4 p.427 ~ p.442
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Poly(lactic acid)/poly(lactic-co-glycolic acid) particulate carriers for pulmonary drug delivery
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Emami Fakhrossadat
Yazdi Seyed Jamaleddin Mostafavi
Na Dong-Hee
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Abstract
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Background: Pulmonary route is an attractive target for both systemic and local drug delivery, with the advantages of a large surface area, rich blood supply, and absence of first-pass metabolism. Numerous polymeric micro/nanoparticles have been designed and studied for controlled and targeted drug delivery to the lung.
Area covered: Among the natural and synthetic polymers for polymeric particles, poly(lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) have been widely used for the delivery of anti-cancer agents, anti-inflammatory drugs, vaccines, peptides, and proteins because of their highly biocompatible and biodegradable properties. This review focuses on the characteristics of PLA/PLGA particles as carriers of drugs for efficient delivery to the lung. Furthermore, the manufacturing techniques of the polymeric particles, and their applications for inhalation therapy were discussed.
Expert opinion: Compared to other carriers including liposomes, PLA/PLGA particles present a high structural integrity providing enhanced stability, higher drug loading, and prolonged drug release. Adequately designed and engineered polymeric particles can contribute to a desirable pulmonary drug delivery characterized by a sustained drug release, prolonged drug action, reduction in the therapeutic dose, and improved patient compliance.
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KEYWORD
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Poly(lactic acid), Poly(lactic-co-glycolic acid), Microparticles, Nanoparticles, Pulmonary drug delivery
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